Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase
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چکیده
منابع مشابه
Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase.
The glucose transporter GLUT4 and the aminopeptidase IRAP (insulin-responsive aminopeptidase) are the major cargo proteins of GSVs (GLUT4 storage vesicles) in adipocytes and myocytes. In the basal state, most GSVs are sequestered in perinuclear and other cytosolic compartments. Following insulin stimulation, GSVs undergo exocytic translocation to insert GLUT4 and IRAP into the plasma membrane. ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2007
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20060793